Advanced Medical

As Japan's population ages, there is a growing need to extend healthy life expectancy through anti-aging therapies.
Nicotinamide adenine dinucleotide (NAD+) is a substance naturally synthesized in the body but decreases with age, contributing to the aging process. Sirtuin genes have been shown to rely on NAD+ to help prevent aging.We specialize in the contract manufacturing of research reagents for aging prevention, focusing on nicotinamide mononucleotide (NMN), which are precursors or enhancers of NAD+ metabolism, NMNH (Reduced NMN), and 5-ALA (5-aminolevulinic acid). Additionally, we provide contract manufacturing services for research reagents used in high-dose vitamin C therapy, which is expected to counteract aging by reducing oxidative stress.Leveraging our in-house expertise, we also screen new anti-aging substances and conduct research and development on liposomal supplements to enhance their bioavailability and efficacy.

Photodynamic therapy (PDT) is a treatment method that selectively damages only tumor tissue without affecting normal tissue by inducing cancer cells to take up a light-sensitive substance and then irradiating them with light. Since the irradiated light has no cytotoxic effect, PDT is considered to be a treatment without serious side effects.
Since a certain level of therapeutic efficacy has been achieved in clinical trials, PDT is expected to become a treatment method following surgery, chemotherapy, radiation therapy, and cancer immunotherapy. Against this background, we have been engaged in the research and development of PDT since its inception, and have accumulated achievements not only in cell and animal experiments but also in clinical trials. Based on the knowledge and experience we have accumulated, we can provide our customers with the liposomes, micelles, and other macromolecular processing of novel light-sensitive substances.

Tumor tissue is said to have an increased vascular permeability compared to normal tissue. As a result, macromolecules of 20-200 nm in size tend to leak out of blood vessels and have a reduced ability to be excreted into lymph vessels. This is called the enhanced permeability and retention (EPR) effect. In the field of drug delivery systems (DDS), research utilizing this phenomenon is being actively conducted. In collaboration with various medical institutions and research institutes, we are working on the research and development of anti-cancer drugs that effectively act on cancers but without side effects through the utilization of liposomes and micelles. We are also focusing on the tumor microenvironment, and are researching drugs that improve tumor stroma and specifically act on cytotoxic T cells.